App may help people with MS ward off cognitive decline

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A smartphone-based app now under development may help people with multiple sclerosis stave off cognitive decline, a new preliminary study shows.

Ralph Benedict, professor of neurology in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, developed the app, called the Conscientiousness Coach.

Benedict first demonstrated a relationship between low levels of conscientiousness and cognitive impairment in multiple sclerosis (MS). Similar data have been published in studies focusing on people with early Alzheimer’s disease.

One of the five established traits of personality, conscientiousness is defined as the extent to which an individual is organized, goal-oriented, and self-disciplined.

Recent preliminary research found that such an app-based behavioral intervention can help people who are low in conscientiousness, and may even contribute to improved work outcomes.

That’s significant because approximately half of those with MS lose their jobs within five years of diagnosis; 80% of people with MS will be forced to leave the workforce before they reach the age of 65.

Does conscientiousness foster resilience?

“Conscientiousness is that sense of ‘I’m on top of it,’” says Benedict, who has studied the link between conscientiousness and MS outcomes for more than a decade.

“Research suggests that a high level of conscientiousness is predictive of better outcomes in neurological illness, and as such may be linked to traditional concepts of cognitive reserve, described as a kind of mental leeway built up over a lifetime that fosters resilience in the face of cerebral injury,” Benedict continues.

By contrast, low levels of conscientiousness are associated with transition from mild cognitive impairment to dementia.

Benedict referred to the now-famous 2009 Nun Study that found that despite exhibiting pathology characteristics of Alzheimer’s disease when autopsies were performed, many of these individuals never exhibited cognitive signs of Alzheimer’s while alive.

“The authors of that study theorized that high cognitive reserve is the buffer to pathology, whereas a person with low cognitive reserve starts to show symptoms of cognitive decline much sooner,” he says.

Benedict was among the first to apply that theory to MS patients regarding the cognitive decline that many of them experience with disease progression.

He and his colleagues at the Buffalo Neuroimaging Analysis Center have previously demonstrated that an MS patient’s level of conscientiousness can even be a predictor of brain atrophy, with patients with low conscientiousness experiencing more neurodegeneration over a shorter period than their highly conscientious counterparts.

Tangible goals for people with MS

“I proposed that conscientiousness may be a way to think about maintaining or boosting cognitive reserve in MS,” Benedict says.

That is the philosophy underlying Conscientiousness Coach, the smartphone app he and his team developed for MS patients that is now being studied in a randomized clinical trial.

In an initial meeting, participants are coached to articulate their value structure, with each value (e.g. those related to family, work, hobbies, spiritual or religious concerns, cultural values, etc.) tied to a set of achievable, measurable goals. Tasks to achieve the goals are scheduled with reminders and a calendar.

“That exercise helps participants set up subordinate and tangible goals, and orients them to their value structure every day,” says Benedict, “to remind them what they are doing and why they are doing it.”

Subsequent meetings take place either in person or through telehealth with continued use of the customized app that has been downloaded onto the patient’s smartphone.

“In the short-term, we are teaching people how to compensate for low conscientiousness,” says Benedict. The small study published in the International Journal of MS Care indicates that this may be an effective approach.

“We believe the therapy is helping those low in conscientiousness to compensate, and hopefully maintain this aspect of cognitive reserve. The app is a practical tool to enhance behaviors that mimic high conscientiousness.”

Benedict is seeking funding in order to conduct larger research studies with the app.

Source: University at Buffalo

The post App may help people with MS ward off cognitive decline appeared first on Futurity.

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