Infective endocarditis (IE)—a bacterial infection in the heart or blood vessels— affects 40,000–50,000 patients in the United States per year and has a 1-year average mortality rate of 30%. People who inject drugs (PWID) tend to be younger and have a higher risk for IE due to the entrance of bacteria in the bloodstream. In fact, IE cases among younger patients and PWID have increased, likely as a result of the ongoing opioid epidemic. A recent analysis published in the Journal of Internal Medicine reveals that the risk of death from IE among young US residents aged 15–44 years old has doubled in the last 2 decades. Additionally, the percentage of PWID among young people who die of IE has reached almost 20%.