Innovation in Medicine

Discovery of a cellular uptake pathway for larger drug molecules

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Specialist researcher holding microscope slide analyzing blood sample working at coronavirus vaccine development during virus examination in microbiology hospital laboratory. Biochemistry experiment

Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug’s key-in-a-lock fit with its target and the drug’s ability to make its way across the cellular membrane and get to that target in the first place.

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