Disturbed gut virome with potent interferonogenic property in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that can affect multiple tissues and organs. Common manifestations of SLE include fever, fatigue, malar rash, oral ulcer, alopecia, arthritis, and nephritis. Women of childbearing age are most likely to suffer from SLE. Currently, there is no cure for SLE, and it lacks an effective and safe treatment regimen because its underlying etiopathogenesis remains elusive.