Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model

Close up of chemical microscope and medical research equipment in scientific laboratory. Liquid examination tool with glass lens and blood samples in vacutainers on professional desk

ACM is a hereditary cardiomyopathy characterized by fibrofatty replacement of the ventricular myocardium, a high risk of life-threatening ventricular arrhythmias, sudden cardiac death, and progressive heart failure. However, the cellular origin of cardiac adipocytes in ACM remains largely unknown.

Elegant hierarchical fiber organization within the bamboo node

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