Innovations

Scientists map genetic evolution of chronic lymphocytic leukemia to Richter’s syndrome

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A network of molecules and atoms of glass and crystals constitute a single system. 3D illustration

Every year, up to 1% of patients with chronic lymphocytic leukemia (CLL), a slow-growing blood cancer, have their disease transform into a far more aggressive cancer, a form of lymphoma known as Richter’s syndrome. For the most part, the genomic changes that underlie this metamorphosis and push it forward have been obscure, hindering advances in treatment.

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