Strategy suggests combining surrogate markers for kidney disease progression in clinical trials

Change in urinary albumin:creatinine ratio (UACR) and glomerular filtration rate (GFR) slope are markers that are individually used as surrogates of chronic kidney disease progression in clinical trials. Investigators recently developed a strategy that combines information from the treatment effects on the two to improve the prediction of treatments’ effects on patient outcomes. Their research will be presented at ASN Kidney Week 2022 November 3–November 6.