Successful or pathological cognitive aging? The ‘frontal preservation, temporal impairment (FPTI)’ hypothesis

Research scientist with gloves holding blood sample on glass in laboratory. Biology doctor analyzing plasma dna for medical discovery in pharmaceutical industry. Science equipment on desk

While most individuals experience cognitive decline with increasing age, with some even suffering from pathological cognitive aging like dementia, others can maintain superior cognitive performance, known as successful cognitive aging (SCA). What characterizes the brains of SCA individuals morphologically and what comprises the difference between brain substrates of successful and pathological cognitive aging is largely unknown yet.

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